Biomarkers and severe asthma: a critical appraisal
Review Alessandra Chiappori1†, Laura De Ferrari1†, Chiara Folli1, Pierluigi Mauri2, Anna Maria Riccio1 and Giorgio Walter Canonica1* *Corresponding author: Giorgio W Canonica canonica@unige.it Clinical and Molecular Allergy 2015, 13:20 doi:10.1186/s12948-015-0027-7 Abstract Severe asthma (SA) is a clinically and etiologically heterogeneous respiratory disease which affects among 5–10 % of asthmatic patients. Despite high-dose therapy, a large patients percentage is not fully controlled and has a poor quality […]
Boston Scientific is proud to launch #UncoveringAsthma a report highlighting the burden of #severeasthma in Europe
Uncovering Asthma English The true impact of Asthma on patients’ lives Nearly a third of people living with severe asthma said that their condition made them feel depressed in the last month. 75% of people with severe asthma would like to know more about a non-drug based procedure if they were suitable for it. […]
Should lung biopsies be performed in patients with severe asthma?
Daniel Doberer, Humberto E. Trejo Bittar, Sally E. Wenzel DOI: 10.1183/16000617.0045-2015 Abstract Asthma, and severe asthma, in particular, is increasingly recognised as a heterogeneous disease. Identifying these different phenotypes of asthma and assigning patients to phenotype-specific treatments is one of the current conundrums in respiratory medicine. Any diagnostic procedure in severe asthma (or any disease) should have two aims: 1) […]
Cost effectiveness of bronchial thermoplasty in patients with severe uncontrolled asthma
Original Article Preview Full text HTML PDF Joe G. Zein MDa*, Michelle C. Menegay MPHb, Mendel E. SingerPhD, MPHb, Serpil C. Erzurum MDa, Thomas R. Gildea MD, MSa,Joseph C. Cicenia III, MDa, Sumita Khatri MDa, Mario Castro MDc& Belinda L. Udeh PhD, MPHd Abstract Rationale: Based on its clinical effectiveness, bronchial thermoplasty (BT) was approved by the Food and Drug Administration in 2010 for the treatment of severe […]
Effects of Bronchial Thermoplasty on Airway Smooth Muscle and Collagen Deposition in Asthma
Annals ATS. DOI: 10.1513/AnnalsATS.201504-208OC Jamila Chakir, Ikhlass Haj-Salem, Delphine Gras, Philippe Joubert, Ève-Léa Beaudoin, Sabrina Biardel, Noel Lampron, Simon Martel, Pascal Chanez, Louis-Philippe Boulet, and Michel Laviolette +Author Information. Corresponding Author: Michel Laviolette, Email: Michel.Laviolette@fmed.ulaval.ca Abstract Rationale: Bronchial thermoplasty aims to improve asthma symptoms by reducing central airway smooth muscle mass. Up to now, the reduction of smooth muscle mass has been documented only for […]
Targeting the interleukin pathway in the treatment of asthma
Volume 386, No. 9998, p1086–1096, 12 September 2015 Series Prof Kian Fan Chung, DSc DOI: http://dx.doi.org/10.1016/S0140-6736(15)00157-9 | Summary Asthma is a common heterogeneous disease with a complex pathophysiology. Current therapies based on inhaled corticosteroids and longacting β2 agonists are effective in controlling asthma in most, but not all patients, with a few patients falling into the severe asthma […]
Allergic rhinitis: the “Ghost Diagnosis” in patients with asthma
Review Maureen Egan and Supinda Bunyavanich Abstract Allergic rhinitis (AR) is a common comorbidity of asthma that contributes to asthma severity. Although over 80 % of asthmatics have AR, the condition is frequently underdiagnosed in subjects with asthma. AR itself is also a highly prevalent condition, affecting 10-30 % of adults and up to 40 % of children. AR has […]
Psychological aspects in asthma: do psychological factors affect asthma management?
Review Ilaria Baiardini*†, Francesca Sicuro†, Francesco Balbi, Giorgio Walter Canonica† and Fulvio Braido† Asthma Research and Practice 2015, 1:7 doi:10.1186/s40733-015-0007-1 Abstract Despite the regular treatment with inhaled corticosteroids (ICS) or ICS plus long-acting beta2-agonists, permits to control de majority of asthmatics, a significant proportion of patients does not respond to this treatment. This review was aimed to explore the role of psychological […]
Long-term efficacy and safety of bronchial thermoplasty in patients with moderate-to-severe persistent asthma: a systemic review and meta-analysis
DOI:10.3109/02770903.2015.1065424 Jian Ping Zhou MDaa, Yun Feng MD, PhDaa, Qiong Wang MDaa, Li Na Zhou MDaa, Huan Ying Wan MDaa & Qing Yun Li MD, PhDaa* Abstract Objective: To evaluate the long-term efficacy and safety of bronchial thermoplasty (BT) in the treatment of patients with moderate-to-severe persistent asthma. Methods: We therefore performed a systematic literature review of peer-reviewed studies focusing on BT intervention in asthma […]
Integrating microbial and host transcriptomics to characterize asthma-associated microbial communities
Eduardo Castro-Nallar15*, Ying Shen2, Robert J. Freishtat3, Marcos Pérez-Losada134, Solaiappan Manimaran2, Gang Liu2, W. Evan Johnson2 and Keith A. Crandall1* *Corresponding authors: Eduardo Castro-Nallar eduardo.castro@unab.cl – Keith A Crandallkcrandall@gwu.edu Author Affiliations BMC Medical Genomics 2015, 8:50 doi:10.1186/s12920-015-0121-1 Abstract Background The relationships between infections in early life and asthma are not completely understood. Likewise, the clinical relevance of microbial communities present in the respiratory tract is only partially known. […]