Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life
Elizabeth R. Davies,1,2 Joanne F.C. Kelly,1 Peter H. Howarth,3,4 David I. Wilson,4,5 Stephen T. Holgate,3,4 Donna E. Davies,1,3,4 Jeffrey A. Whitsett,2 and Hans Michael Haitchi1,2,3,4 JCI Insight. 2016;1(11):e87632. doi:10.1172/jci.insight.87632. Research Article Pulmonology Abstract Asthma is a chronic inflammatory airways disease that usually begins in early life and involves gene-environment interactions. Although most asthma exhibits allergic inflammation, many allergic individuals do not have asthma. Here, we […]
Association Between Unconventional Natural Gas Development in the Marcellus Shale and Asthma Exacerbations
Original Investigation | July 18, 2016 FREE ONLINE FIRST Sara G. Rasmussen, MHS1; Elizabeth L. Ogburn, PhD2; Meredith McCormack, MD3; Joan A. Casey, PhD4; Karen Bandeen-Roche, PhD2; Dione G. Mercer, BS5; Brian S. Schwartz, MD, MS1,3,5 [+] Author Affiliations JAMA Intern Med. Published online July 18, 2016. doi:10.1001/jamainternmed.2016.2436 ABSTRACT ABSTRACT | INTRODUCTION | METHODS | RESULTS | DISCUSSION | CONCLUSIONS |ARTICLE INFORMATION | REFERENCES Importance Asthma is common and can be exacerbated by air pollution and stress. Unconventional natural gas development (UNGD) has community and environmental impacts. In […]
Urbanization is associated with increased asthma morbidity and mortality in Brazil
Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) Eduardo Vieira Ponte PhD1,*, Alvaro A. Cruz PhD2, Rodrigo Athanazio EdD3, Regina Carvalho-Pinto PhD4, Frederico L. A. Fernandes EdD5, Mauricio L. Barreto PhD6 and Rafael Stelmach PhD7 Abstract Introduction: Previous cross sectional studies could establish […]
Analysis of the quality of life of patients with asthma and allergic rhinitis after immunotherapy
Original paper Małgorzata Filanowicz, Ewa Szynkiewicz, Bernadeta Cegła, Zbigniew Bartuzi Adv Dermatol Allergol 2016; XXXIII (2): 134–141 DOI (digital object identifier): 10.5114/pdia.2015.48061 Aim: To assess the quality of life of Polish patients with asthma and/or allergic rhinitis before the implementation and after 30–36 months of immunotherapy. Material and methods: Two hundred patients have been involved […]
REVIEW – Emerging technologies for the diagnosis, treatment and management of refractory asthma
Technology Description: The NIHR Horizon Scanning Research and Intelligence Centre has published a horizon scanning review about health technologies in development for patients with refractory asthma. Refractory asthma is a poorly understood, poorly defined, complex heterogeneous disease in which adequate asthma control cannot be achieved or sustained in a substantial proportion of patients. Refractory asthma […]
IgE mediated sensitisation to aeroallergens in an asthmatic cohort: relationship with inflammatory phenotypes and disease severity
Volume 70, Issue 7, pages 596–605, July 2016 M. Manise, B. Bakayoko, F. Schleich, J.-L. Corhay and R. Louis Summary Background Atopy is known to play an important role in the asthmatic disease. The main objective of this study was to evaluate the frequency of sensitisation to common aeroallergens in a cohort of asthmatics with different inflammatory […]
Microbes and asthma: Opportunities for intervention
March 2016 Volume 137, Issue 3, Pages 690–697 Hermelijn H. Smits, Pieter S. Hiemstra, PhD, Clarissa Prazeres da Costa, MD, PhD, Markus Ege, MPH, Michael Edwards, PhD, Holger Garn, PhD, Peter H. Howarth, MD, Tuomas Jartti, MD, Esther C. de Jong, PhD, Rick M. Maizels, PhD, Ben J. Marsland, PhD, Henry J. McSorley, PhD, Anne Müller, PhD, […]
Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma
DOI: http://dx.doi.org/10.1016/S2213-2600(16)30018-2 In Press, Corrected Proof Abhaya Trivedi, MD, Prof Ian D Pavord, MD, Prof Mario Castro, MD Summary Although a small proportion of patients with asthma have severe disease, it accounts for the majority of morbidity related to the illness. Severe asthma comprises a heterogeneous group of phenotypes. Targeted treatments for these phenotypes represent a major […]
The management of asthmatic smokers
Asthma Research and Practice 2016 2:10 DOI: 10.1186/s40733-016-0025-7 José Miguel Chatkin Email author and Cynthia Rocha Dullius Abstract Asthma is still a major public health problem in most countries; new strategies to better control this disease are necessary. Such strategies must include predisposing factors. One of these factors is smoking and a significant fraction of asthmatics are smokers. However, clinical trials studying new […]
e-Monitoring of Asthma Therapy to Improve Compliance in children (e-MATIC): a randomised controlled trial
Erwin C. Vasbinder, Lucas M.A. Goossens, Maureen P.M.H. Rutten-van Mölken, Brenda C.M. de Winter, Liset van Dijk, Arnold G. Vulto, Ellen I.M. Blankman, Nordin Dahhan,Monique T.M. Veenstra-van Schie, Florens G.A. Versteegh, Bart H.M. Wolf, Hettie M. Janssens, Patricia M.L.A. van den Bemt DOI: 10.1183/13993003.01698-2015 Published 26 May 2016 Abstract Real-time medication monitoring (RTMM) is a promising tool for improving adherence to inhaled corticosteroids (ICS), but has not been sufficiently tested in children with asthma. We aimed to study the effects of RTMM […]