The Effectiveness of Web-Based Asthma Self-Management System, My Asthma Portal (MAP): A Pilot Randomized Controlled Trial
Original Paper Sara Ahmed1,2,3,4, BPhysio, MSc (Rehab), PhD ; Pierre Ernst5, FRCPC, MD ; Susan J Bartlett1,3, PhD ; Marie-France Valois3, MSc ; Tasneem Zaihra1,2,4,6, PhD ; Guy Paré7, PhD ; Roland Grad8, MSc, FCFP, MDCM ; Owis Eilayyan1,2,4, MSc ; Robert Perreault9, FRCPC, MD ; Robyn Tamblyn3,10, PhD 1Division of Clinical Epidemiology, McGill University Health Center, McGill University, Montreal, QC, Canada 2School of Physical & Occupational Therapy, Faculty of Medicine, McGill University, Montreal, […]
Should recommendations about starting inhaled corticosteroid treatment for mild asthma be based on symptom frequency: a post-hoc efficacy analysis of the START study
Prof Helen K Reddel, PhD, William W Busse, MD, Søren Pedersen, DMed Sci, Wan C Tan, MB, Yu-Zhi Chen, MD, Carin Jorup, MD, Dan Lythgoe, MSc, Paul M O’Byrne, MD DOI: http://dx.doi.org/10.1016/S0140-6736(16)31399-X Summary Background Low-dose inhaled corticosteroids (ICS) are highly effective for reducing asthma exacerbations and mortality. Conventionally, ICS treatment is recommended for patients with symptoms […]
What are the pros and cons of electronically monitoring inhaler use in asthma? A multistakeholder perspective
BMJ Open Resp Res 2016;3:e000159 doi:10.1136/bmjresp-2016-000159 Sam Howard1, Alexandra Lang1, Sarah Sharples1 and Dominick Shaw2 +Author Affiliations 1Human Factors Research Group, Innovation and Technology Research Centre, University of Nottingham, Nottingham, UK 2Division of Respiratory Medicine, School of Medicine, Nottingham City Hospital, University of Nottingham, Nottingham, UK Abstract Introduction Electronic monitoring devices (EMDs) are the optimal method for collecting objective data on inhaler use in […]
Severe asthma: Current management, targeted therapies and future directions—A roundtable report
Invited Review Series: Seeking Innovative Solutions in Severe Asthma Authors Vanessa M. McDonald, Steven Maltby, Helen K. Reddel, Gregory G. King, Peter A.B. Wark, Lorraine Smith, John W. Upham, Alan L. James, Guy B. Marks, Peter G. Gibson ABSTRACT Asthma is a chronic respiratory disease characterized by respiratory symptoms, airway inflammation, airway obstruction and airway […]
Propofol and Remifentanil Sedation for Bronchial Thermoplasty: A Prospective Cohort Trial
Respiration (DOI:10.1159/000452478) d’Hooghe J.N.S.a · Eberl S.b · Annema J.T.a · Bonta P.I.a Departments of a Pulmonology and b Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Abstract Background: Bronchial thermoplasty (BT) is a rapidly emerging bronchoscopic treatment for patients with moderate-to-severe asthma. Different sedation strategies are currently used, ranging from mild midazolam sedation to general anesthesia requiring tracheal intubation. Objectives: The aim of this […]
Association Between Allergen Exposure in Inner-City Schools and Asthma Morbidity Among Students
JAMA Pediatrics William J. Sheehan, MD1,2; Perdita Permaul, MD2,3; Carter R. Petty, MA4; et alBrent A. Coull, PhD5; Sachin N. Baxi, MD1,2; Jonathan M. Gaffin, MD, MMsc2,6; Peggy S. Lai, MD, MPH2,5,7; Diane R. Gold, MD, MPH2,5,8; Wanda Phipatanakul, MD, MS1,2 Author Affiliations Article Information JAMA Pediatr. Published online November 21, 2016. doi:10.1001/jamapediatrics.2016.2543 Key Points Question What is the effect of school-specific aeroallergen exposures on students’ asthma morbidity? Findings In this cohort study evaluating students with asthma, higher mouse allergen exposure at school was […]
Are sleep disorders associated with increased mortality in asthma patients?
BMC Pulmonary Medicine RESEARCH ARTICLE – OPEN ACCESS – OPEN PEER REVIEW Kyu-Tae Han†, Hong-Chul Bae†, Sang Gyu Lee, Seung Ju Kim, Woorim Kim, Hyo Jung Lee, Yeong Jun Ju and Eun-Cheol Park †Contributed equally BMC Pulmonary Medicine BMC series – open, inclusive and trusted 2016 16:154 DOI: 10.1186/s12890-016-0313-2 Open Peer Review reports Abstract Background South Korea has experienced problems regarding poor management of symptoms of asthma patients and remarkable increases […]
Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study
BMC Pulmonary Medicine RESEARCH ARTICLE – OPEN ACCESS – OPEN PEER REVIEW BMC Pulmonary Medicine BMC series – open, inclusive and trusted 2016 16:152 DOI: 10.1186/s12890-016-0312-3 Te-Chun Shen, Hsuan-Ju Chen, Chang-Ching Wei, Chia-Hung Chen, Chih-Yen Tu, Te-Chun Hsia, Chuen-Ming Shih, Wu-Huei Hsu, Fung-Chang Sung†Email author and Da-Tian Bau† Email author Open Peer Review reports Abstract Background Sjögren’s syndrome (SS) has been associated with bronchial hyperresponsiveness and asthma; however, no population-based cohort study has been performed. We evaluated the risk of […]
Development of New Therapies for Severe Asthma
Allergy Asthma Immunol Res. 2017 Jan;9(1):3-14. English. Open Access Merritt L. Fajt and Sally E. Wenzel Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Asthma Institute at UPMC/University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Abstract Persistent asthma has long been treated with inhaled corticosteroids (CSs), as the […]
Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients
Respiratory Research RESEARCH – OPEN ACCESS Respiratory Research 201617:124 Thomas Southworth Email author, Jonathan Plumb, Vandana Gupta, James Pearson, Isabel Ramis, Martin D. Lehner, Montserrat Miralpeix and Dave Singh Abstract Background Phosphatidylinositol 3-kinase delta (PI3Kδ) and Janus-activated kinases (JAK) are both novel anti-inflammatory targets in asthma that affect lymphocyte activation. We have investigated the anti-inflammatory effects of PI3Kδ and JAK inhibition on cytokine release […]