Efficacy and Safety of Anti-Interleukin-5 Therapy in Patients with Asthma: A Systematic Review and Meta-Analysis
Published: November 22, 2016http://dx.doi.org/10.1371/journal.pone.0166833 Fa-Ping Wang ,Ting Liu , Zhu Lan, Su-Yun Li, Hui Mao Abstract Background Recent trials have assessed the efficacy and safety of novel monoclonal antibodies such as reslizumab and benralizumab. However, the overall efficacy and safety anti—interleukin (IL) 5 treatment in asthma have not been thoroughly assessed. Methods Randomized controlled trials (RCTs) […]
Asthma in children: can serum tryptase levels predict disease severity?
Int Arch Allergy Immunol 2016;171:194-202 (DOI:10.1159/000452624) Diagnostic Value of Serum Baseline Tryptase Levels in Childhood Asthma and Its Correlation with Disease Severity Gao S. · Fan J. · Wang Z. Department of Pediatrics, Linyi People’s Hospital, Linyi City, China Corresponding Author Abstract FullText PDF Abstract Background: The aim of this study was to explore whether […]
Spotlight on fluticasone furoate/vilanterol trifenatate for the once-daily treatment of asthma: design, development and place in therapy
Drug Des Devel Ther. 2016; 10: 4047–4060. Published online 2016 Dec 14. doi: 10.2147/DDDT.S113573 Timothy E Albertson,1,2,3 Samuel W Bullick,1,3 Michael Schivo,1 and Mark E Sutter2,3 Author information ► Copyright and License information ► Abstract The use of inhaled corticosteroids (ICSs) plays a key role in the treatment of asthmatic patients, and international guidelines have designated ICSs as an early maintenance therapy in controlling […]
Near-fatal asthma: a heterogeneous clinical entity
MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by J Andrew Grant and Gustavo J Rodrigo Serrano-Pariente, José; Plaza, Vicente Abstract Purpose of review: The aims of the present review were to describe the heterogeneous nature of near-fatal asthma (NFA) and to summarize the distinctive phenotypes identified in this subtype of asthma. Recent findings: Clinical, […]
Bronchial Thermoplasty for Severe Asthma: A Review of the Clinical and Cost-Effectiveness, and Guidelines
Rapid Response Report: Summary with Critical Appraisal Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Aug 27. Copyright and Permissions Severe asthma is a chronic condition in which patients experience airway inflammation and airway muscle contraction leading to symptoms of breathlessness, wheezing, coughing, and chest tightness. It is one of the most common chronic conditions with an estimated 235 million people affected worldwide, an […]
Fatal asthma; is it still an epidemic?
World Allergy Organ J. 2016; 9(1): 42. Published online 2016 Dec 14. doi: 10.1186/s40413-016-0129-9 PMCID: PMC5155395 Andrea Vianello,1 Marco Caminati,2 Mariangiola Crivellaro,3 Rafi El Mazloum,4 Rossella Snenghi,4 Michele Schiappoli,2 Annarita Dama,2 Andrea Rossi,2 Giuliana Festi,2 Maria Rita Marchi,1 Chiara Bovo,5 Giorgio Walter Canonica,6 and Gianenrico Senna2 Author information ► Article notes ► Copyright and License information ► Abstract Background Asthma mortality has declined since the 1980s. Nevertheless the World Health Organization (WHO) identified asthma as […]
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Prenatal exposure to selenium may protect against wheezing in children by the age of 3
Early View Browse Early View Articles Original Research Authors: Nour Baïz, Julie Chastang, Gladys Ibanez, Isabella Annesi-Maesano Abstract Introduction It has been suggested that human in utero exposure to heavy metals such as selenium can reduce the prevalence of childhood asthma and allergic diseases. However, data on this topic are scarce. The objective of the present […]
Suicidal ideation and suicide attempts among asthma
Ann Gen Psychiatry. 2016 Nov 29;15:35. eCollection 2016. Chung JH1, Kim SH2, Lee YW1. Author information Abstract BACKGROUND: The present study aimed to investigate the mental health status in patients with asthma and assess the effects of asthma on suicidal ideation and attempts using a representative sample from Korea. METHODS: Individual-level data were obtained from 228,744 participants (6372 […]
Procedural and short-term safety of bronchial thermoplasty in clinical practice: evidence from a national registry and Hospital Episode Statistics.
J Asthma. 2016 Dec 1:0. [Epub ahead of print] Burn J1, Sims AJ1, Keltie K1, Patrick H2, Welham SA3, Heaney LG4, Niven R5. Author information Abstract OBJECTIVE: Bronchial thermoplasty (BT) is a novel treatment for severe asthma. Its mode of action and ideal target patient group remain poorly defined, though clinical trials provided some evidence on efficacy and safety. This study presents procedural […]