New for Journal of Asthma online now:
Research Article COVID-19 vaccine uptake and hesitancy in Chinese patients with asthmaChun Chang MD, PhD, Xiaoqin Zhang MM, Yu Feng MBBS, Rong Jin MD, Lina Sun MD, Ying Liang MD, Xiaofang Liu MD, PhD, Yanliang Ma MD, Jie Song MBBS, Pingchao Xiang MBBS, Erming Zhang MBBS, Liang Chen MBBS, Yanwen Jiang MD, Kewu Huang MD, […]
Infants With Siblings Protected From Food Allergy via Microbiota Maturation
Ron Goldberg In infants with older siblings, advanced maturation of gut microbiota at 1 year of age significantly mediates the risk of developing immunoglobulin E (IgE)-mediated food allergy during infancy, according to study findings published in The Journal of Allergy and Clinical Immunology. Having siblings and household pets, particularly dogs, seems to have a protective effect […]
Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study
Summary Background Validated questionnaires are used to assess asthma control over the past 1–4 weeks from reporting. However, they do not adequately capture asthma control in patients with fluctuating symptoms. Using the Mobile Airways Sentinel Network for airway diseases (MASK-air) app, we developed and validated an electronic daily asthma control score (e-DASTHMA). Methods We used […]
Economic impact of a more extensive use of FENO testing on the Italian population with asthma
Research – Open Access Carla Rognoni, Carlo Milano, Enrico Heffler, Matteo Bonini, Luisa Brussino, Giovanna Elisiana Carpagnano, Fabio Luigi Massimo Ricciardolo, Francesco Costa & Patrizio Armeni Respiratory Research volume 24, Article number: 147 (2023) Abstract Background Asthma is a common chronic inflammatory airway affecting over 260 million people worldwide, and characterized, in the large majority of cases, by the so-called “type 2 inflammation”. Fractional exhaled nitric oxide (FENO) testing is […]
Precision Medicine in Severe Asthma Predicts Lack of Benefit From Biologics
Ron Goldberg A precision medicine approach to severe asthma treatment can identify patients who will have minimal benefit from biologic therapy with mepolizumab, based on numerous patient characteristics, according to post-hoc analysis published in Respiratory Research. Due to the high cost of biologic treatment for asthma, there is value to being able to predict whether a […]
Predictors/Trajectories of Depressive Symptoms in Asthma, From Youth to Adulthood
Ron Goldberg Racial marginalization and socioeconomic disadvantage are associated with greater baseline depressive symptoms in individuals with asthma, with depressive symptoms decelerating across adolescence and into young adulthood and then increasing across young adulthood and into adulthood. These were among study findings published in the Journal of Pediatric Psychology. Asthma accompanied by depression is associated with […]
Impact of a digital web-based asthma platform, a real-life study
Genberg EM, Viitanen HT, Mäkelä MJ, Kautiainen HJ, Kauppi PM. BMC Pulm Med. 2023 May 12;23(1):165. doi: 10.1186/s12890-023-02467-8. Abstract Background Digital health technology (DHT) is a growing area in the treatment of chronic diseases. Study results on DHT’s effect on asthma control have been mixed, but benefits have been seen for adherence, self-management, symptoms, and […]
The association of spirometric small airways obstruction with respiratory symptoms, cardiometabolic diseases, and quality of life: results from the Burden of Obstructive Lung Disease (BOLD) study
Knox-Brown B, Patel J, Potts J, Ahmed R et al. Respir Res. 2023 May 23;24(1):137. doi: 10.1186/s12931-023-02450-1. Abstract Background Spirometric small airways obstruction (SAO) is common in the general population. Whether spirometric SAO is associated with respiratory symptoms, cardiometabolic diseases, and quality of life (QoL) is unknown. Methods Using data from the Burden of Obstructive […]
Long-term effectiveness of benralizumab in severe eosinophilic asthma patients treated for 96-weeks: data from the ANANKE study
Research – Open Access Alessandra Vultaggio, Maria Aliani, Elena Altieri, Pietro Bracciale, Luisa Brussino, Maria Filomena Caiaffa, Paolo Cameli, Giorgio Walter Canonica, Cristiano Caruso, Stefano Centanni, Maria D’Amato, Fausto De Michele, Stefano Del Giacco, Fabiano Di Marco, Francesco Menzella, Girolamo Pelaia, Paola Rogliani, Micaela Romagnoli, Pietro Schino, Gianenrico Senna, Marco Benci, Silvia Boarino & Jan Walter Schroeder Respiratory Research volume 24, Article number: 135 (2023) Abstract Background The efficacy of benralizumab has been broadly demonstrated in severe eosinophilic asthma (SEA), but only few […]
T helper 2 cells in asthma
Harker JA, Lloyd CM. J Exp Med. 2023 Jun 5;220(6):e20221094. doi: 10.1084/jem.20221094. Abstract: Allergic asthma is among the most common immune-mediated diseases across the world, and type 2 immune responses are thought to be central to pathogenesis. The importance of T helper 2 (Th2) cells as central regulators of type 2 responses in asthma has, […]