Type-2 CD8+ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations
Article – Open Access Esmee K. van der Ploeg, Lisette Krabbendam, Heleen Vroman, Menno van Nimwegen, Marjolein J. W. de Bruijn, Geertje M. de Boer, Ingrid M. Bergen, Mirjam Kool, Gerdien A. Tramper-Standers, Gert-Jan Braunstahl, Danny Huylebroeck, Rudi W. Hendriks & Ralph Stadhouders Nature Communications volume 14, Article number: 5137 (2023) Abstract CD4+ T helper 2 (Th2) cells and group 2 innate lymphoid cells are considered the main producers of type-2 cytokines that fuel […]
Wildfire PM2.5 Linked to Increase in Incidence of Asthma ED Visits
Wildfire fine particulate matter (PM2.5) is associated with a significant increase in the incidence of same-day asthma emergency department (ED) visits, but the increase was only slightly higher than that seen on high pollen count days. HealthDay News — Wildfire fine particulate matter (PM2.5) is associated with a significant increase in the incidence of same-day […]
New for Journal of Asthma online now
Case Report Efficacy of mepolizumab and omalizumab combination therapy in uncontrolled asthmaMehmet Emin Sezgin MD, Mustafa Çolak MD, Özge Çağlayan MD, Merve Yumrukuz Şenel MD, Esma Nur Aktepe Sezgin MD, Hikmet Çoban MD, Nurhan Sarıoğlu MD, Bilun Gemicioğlu MD & Fuat Erel MDPages: 1-3 | DOI: 10.1080/02770903.2023.2244590 “Patient remodeling” as a consequence of uncontrolled and […]
Evaluation of the use of methylprednisolone and dexamethasone in asthma critically ill patients with COVID-19: a multicenter cohort study
Research – Open Access Khalid Al Sulaiman, Ohoud Aljuhani, Ghazwa B. Korayem, Ali Altebainawi, Reham Alharbi, Maha Assadoon, Ramesh Vishwakarma, Nadia H. Ismail, Asma A. Alshehri, Faisal E. Al Mutairi, Mashael AlFaifi, Abdullah F. Alharthi, Abeer A. Alenazi, Mai Alalawi, Omar Al Zumai, Hussain Al Haji, Sarah T. Al Dughaish, Abdulrahman S. Alawaji, Haifa A. Alhaidal & Ghassan Al Ghamdi BMC Pulmonary Medicine volume 23, Article number: 315 (2023) Abstract Background Previous studies have shown mortality benefits with corticosteroids in […]
Clinical standards for the diagnosis and management of asthma in low- and middle-income countries
Jayasooriya, S. 1 ; Stolbrink, M. 2 ; Khoo, E. M. 3 ; Sunte, I. T. 4 ; Awuru, J. I. 4 ; Cohen, M. 5 ; Lam, D. C. 6 ; Spanevello, A. 7 ; Visca, D. 8 ; Centis, R. 9 ; Migliori, G. B. 9 ; Ayuk, A.C. 10 ; Buendia, J.A. 11 ; Awokola, B. I. 12 ; Del-Rio-Navarro, B. E. 13 ; Muteti-Fana, S. 14 ; Lao-araya, M. 15 ; Chiarella, P. 16 ; Badellino, H 17 ; Somwe, S. W. 18 ; Anand, M. P. 19 ; Garcí-Corzo, J. R. 20 ; Bekele, A. 21 ; Soto-Martinez, M. E. 22 ; Ngahane, B. H. M. 23 ; Florin, M. 24 ; Voyi, K. 25 ; Tabbah, K. 26 ; Bakki, B. 27 ; Alexander, A. 28 ; Garba, B. L. 29 ; Salvador, E. M. 30 ; Fischer, G. B. 31 ; Falade, A. G. 32 ; ŽivkoviĆ, Zorica 33 ; Romero-Tapia, S. J. 34 ; Erhabor, […]
Bronchodilator Response Not Linked to Poor Asthma Control or Symptoms
Colby Stong A bronchodilator response (BDR) is not associated with asthma control or symptoms among patients with poorly controlled asthma, regardless of the definition of BDR that is used, according to study findings published in Respiratory Medicine. Researchers sought to determine the relationship between BDR and asthma control and symptom burden in patients with poorly controlled […]
Circulating CC16 Levels Are Inversely to Active Asthma
Colby Stong A single standard-deviation reduction in CC16 concentrations increased the odds for active asthma by 20%. Deficits in circulating Club cell secretory protein (CC16) levels are strongly and independently associated with asthma, especially asthma with frequent symptoms, from childhood through mid-adult life, according to a study in the American Journal of Respiratory and Critical Care […]
New for Journal of Asthma online now:
Research Article In symptomatic patients on as-needed inhaled corticosteroids-formoterol, VAS asthma is associated with small airways resistanceIlgim Vardaloglu, Bernardo Sousa-Pinto, Jean Bousquet, Peter Dodek, Anna Bedbrook, Mert Karatas & Bilun GemiciogluPages: 1-11 | DOI: 10.1080/02770903.2023.2248485 This is the author accepted version which has not been proofed or edited Serum levels of interleukin-33, soluble ST2 and […]
Rhinovirus infection induces secretion of endothelin-1 from airway epithelial cells in both in vitro and in vivo models
Research – Open Access Alane Blythe C. Dy, Jason Girkin, Antonella Marrocco, Adam Collison, Chimwemwe Mwase, Michael J. O’Sullivan, Thien-Khoi N. Phung, Joerg Mattes, Cynthia Koziol-White, James E. Gern, Yury A. Bochkov, Nathan W. Bartlett & Jin-Ah Park Respiratory Research volume 24, Article number: 205 (2023) Abstract Background Rhinovirus (RV) infection of airway epithelial cells triggers asthma exacerbations, during which airway smooth muscle (ASM) excessively contracts. Due to ASM contraction, airway epithelial cells […]
Asthma hospitalisations and heat exposure in England: a case–crossover study during 2002–2019
Konstantinoudis G, Minelli C, Lam HCY, Fuertes E, Ballester J, Davies B, Vicedo-Cabrera AM, Gasparrini A, Blangiardo M. Asthma hospitalisations and heat exposure in England: a case-crossover study during 2002-2019. Thorax. 2023 Sep;78(9):875-881. doi: 10.1136/thorax-2022-219901. Open Access. Abstract Background Previous studies have reported an association between warm temperature and asthma hospitalisation. They have reported different sex-related and […]