Association between prevalence of obstructive lung disease and obesity: results from The Vermont Diabetes Information System
Research Open Access Maria E. Ramos-Nino, Charles D. MacLean & Benjamin Littenberg Asthma Research and Practice volume 7, Article number: 6 (2021) Abstract Background The association of obesity with the development of obstructive lung disease, namely asthma and/or chronic obstructive pulmonary disease, has been found to be significant in general population studies, and weight loss in the obese has proven beneficial in disease […]
RORγt inhibitors block both IL-17 and IL-22 conferring a potential advantage over anti-IL-17 alone to treat severe asthma
Research – Open Access David Lamb, Dorothy De Sousa, Karsten Quast, Katrin Fundel-Clemens, Jonas S. Erjefält, Caroline Sandén, Hans Jürgen Hoffmann, Marc Kästle, Ramona Schmid, Kevin Menden & Denis Delic Respiratory Research volume 22, Article number: 158 (2021) Abstract Background RORγt is a transcription factor that enables elaboration of Th17-associated cytokines (including IL-17 and IL-22) and is proposed as a pharmacological target for severe asthma. Methods IL-17 immunohistochemistry was performed in […]
Journal of Asthma, Volume 58, Issue 6, June 2021 is now available online on Taylor & Francis Online
Immunopathogenesis Elevated Th17 cell frequencies and Th17/Treg ratio are associated with airway hyperresponsiveness in asthmatic childrenRongying Zheng MD, Fangmin Wang MD, Yue Huang MD, Qiangwei Xiang MD, Huan Dai MD & Weixi Zhang MD, PhDPages: 707-716 | DOI: 10.1080/02770903.2020.1737710Biomarkers Expression of herpesvirus entry mediator gene as a potential biomarker for disease severity in patients with persistent asthmaYi […]
New for Journal of Asthma and online now on Taylor & Francis Online:
Articles Physical Activity, Sleep and Quality of Life of Patients with Asthma during the COVID-19 PandemicKübra Ayşe Daşdemir & Sinem Suner KeklikPages: 1-11 | DOI: 10.1080/02770903.2021.1931303 Medical care and treatment of children with asthmatic or wheezing health outcomes and urban-rural differences in Bavaria – a cross-sectional studySusanne Kutzora, Daniela Herrera Reyes, Alisa Weber, Jonas Huß, Uta […]
Tezepelumab Biologics License Application Submitted for Severe Asthma
Brian Park, PharmD The Biologics License Application (BLA) for tezepelumab has been submitted to the Food and Drug Administration (FDA) for patients with severe asthma. Tezepelumab is an investigational first-in-class human monoclonal antibody that works by blocking thymic stromal lymphopoietin, an epithelial cytokine involved in the initiation and persistence of airway inflammation. Patients were randomly […]
Characteristics of inflammatory phenotypes among patients with asthma: relationships of blood count parameters with sputum cellular phenotypes
Research – Open Access Bingqing Shi, Wei Li, Yuqiu Hao, Hongna Dong, Wenjing Cao, Jie Guo & Peng Gao Allergy, Asthma & Clinical Immunology volume 17, Article number: 47 (2021) Abstract Background There is a need to identify the asthma inflammatory phenotypes of patients to facilitate personalized asthma treatment. Sputum induction is time-consuming and requires expert clinical technique. This study aimed to assess the distribution and characteristics […]
2021 update of the Global Strategy for Asthma Management and Prevention
The 2021 update of the Global Strategy for Asthma Management and Prevention incorporates new scientific information about asthma based on a review of recent scientific literature by an international panel of experts on the GINA Science Committee. PDF
Perception of Health in Caregivers of Children With Asthma and Comorbid Obesity
Bryant Moeller The caregivers of children with comorbid asthma and obesity had an overall perception of worse health compared with caregivers of children with asthma alone, according to the results of a recent study published in the Journal of Asthma. Researchers used results from the 2007-2018 National Health and Nutrition Examination Surveys (NHANES) datasets to analyze […]
Differential Gene Expressions in Cough Variant Asthma and Classical Asthma
Virginia A. Schad, PharmD, RPh The pathogenesis of cough variant asthma and classical asthma may be related to genes such as FCER1A, HDC, and IL4, according to study results published in the Journal of Asthma. Cough variant asthma is considered as a precursor to classical asthma; however, the mechanism of asthma has not been fully elucidated. Therefore, researchers conducted […]
American Lung Association Report Shows 40% of US Regularly Breathes Polluted Air
Brandon May The American Lung Association’s (ALA) 22nd annual “State of the Air” report shows that approximately 135 million people in the United States — or, 4 in 10 Americans — breathe polluted air on a regular basis, and people of color are more than 3 times more likely than White individuals to live in […]