Year: 2018

Virus-triggered exacerbation in allergic asthmatic children: neutrophilic airway inflammation and alteration of virus sensors characterize a subgroup of patients

Respiratory Research Research Open Access   Antoine Deschildre, Muriel Pichavant, Ilka Engelmann, Carole Langlois, Elodie Drumez, Guillaume Pouessel, Sophie Boileau, David Romero-Cubero, Irina Decleyre-Badiu, Anny Dewilde, Didier Hober, Véronique Néve, Caroline Thumerelle, Stéphanie Lejeune, Clémence Mordacq and Philippe Gosset Respiratory Research 201718:191 Abstract Background Viruses are important triggers of asthma exacerbations. They are also detected outside of exacerbation. Alteration of anti-viral response in asthmatic patients has been shown although the mechanisms responsible for this […]

Role of airway epithelial barrier dysfunction in pathogenesis of asthma

Allergology International Volume 67, Issue 1, January 2018, Pages 12-17 Yasuhiro Gon,  Shu Hashimoto Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan Open Access Article Info Abstract Bronchial asthma is characterized by persistent cough, increased sputum, and repeated wheezing. The pathophysiology underlying these symptoms is the hyper-responsiveness of the airway […]

Assessment of knowledge and education relating to asthma during pregnancy among women of childbearing age

Asthma Research and Practice Mohammed O. Al Ghobain, Mohammed AlNemer and Mohammad Khan Asthma Research and Practice 2018 4:2   https://doi.org/10.1186/s40733-017-0038-x Abstract Background Misconceptions about medications’ safety can lead pregnant women with asthma to stop their medications, resulting in asthma-related neonatal morbidity and mortality. Our aim was to assess the level of pregnancy-related asthma knowledge and education about asthma medications’ safety, among women […]

Risk factors of postoperative pulmonary complications in patients with asthma and COPD

BMC Pulmonary Medicine   Research article    Open Access   Open Peer Review Takanori Numata, Katsutoshi Nakayama, Satoko Fujii, Yoko Yumino, Nayuta Saito, Masahiro Yoshida, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara, Jun Araya, Yumi Kaneko and Kazuyoshi Kuwano BMC Pulmonary Medicine BMC series – open, inclusive and trusted 2018 18:4 https://doi.org/10.1186/s12890-017-0570-8 Open Peer Review reports Abstract Background Postoperative pulmonary complications (PPC) in patients with pulmonary diseases remain to be resolved clinical issue. However, most evidence regarding PPC has been established more than […]

Effect of the School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) Program on Asthma Morbidity A Randomized Clinical Trial

  JAMA Pediatrics Jill S. Halterman, MD, MPH1; Maria Fagnano, MPH1; Reynaldo S. Tajon, BA1; et alPaul Tremblay, RN1; Hongyue Wang, PhD2; Arlene Butz, ScD, RN3; Tamara T. Perry, MD4; Kenneth M. McConnochie, MD, MPH1 Author Affiliations Article Information JAMA Pediatr. Published online January 8, 2018. doi:10.1001/jamapediatrics.2017.4938   Key Points Question  Can a novel school-based intervention that includes supervised asthma therapy and telemedicine visits overcome key barriers to guideline-based preventive care and improve outcomes for urban children with asthma? Findings  In this randomized […]

Physician perspectives on the burden and management of asthma in six countries: The Global Asthma Physician Survey (GAPS)

Kenneth R. Chapman, David Hinds, Peter Piazza, Chantal Raherison, Michael Gibbs, Timm Greulich, Kenneth Gaalswyk, Jiangtao Lin, Mitsuru Adachi and Kourtney J. Davis BMC Pulmonary Medicine BMC series – open, inclusive and trusted 2017 17:153 Open Peer Review reports Abstract Background Despite recognition of asthma as a growing global issue and development of global guidelines, asthma treatment practices vary between countries. Several studies have reported patients’ perspectives on asthma control. This study presents physicians’ perspectives and strategies for asthma […]

Recovery of hypothalamo–pituitary–adrenal axis suppression during treatment with inhaled corticosteroids for childhood asthma

 Journal of Asthma and Allergy » Volume 10 – Pages 317—326 Gangadharan A, McCoy P, Phyo A, McGuigan MP, Dharmaraj P, Ramakrishnan R, McNamara PS, Blair J Objective: To describe recovery of adrenal insufficiency in asthmatic children treated with inhaled corticosteroids (ICS) and cortisol replacement therapy.Design: Retrospective, observational study.Patients: A total of 113 patients, 74 male; age 10.4 (3.3–16.5) years; beclomethasone-­equivalent ICS dose, 800 µg, […]

New Article From Asthma Research and Practice

Review – Open Access Microbiome and asthma Milena Sokolowska, Remo Frei, Nonhlanhla Lunjani, Cezmi A. Akdis and Liam O’Mahony Asthma Research and Practice 4:1, 2018 Abstract The mucosal immune system is in constant communication with the vast diversity of microbes present on body surfaces. The discovery of novel molecular mechanisms, which mediate host-microbe communication, have highlighted the important roles played by microbes in influencing mucosal immune responses. […]