Year: 2018

New article published in Asthma Research and Practice: Single nucleotide polymorphisms in asthma candidate genes TBXA2R, ADAM33 FCER1B and ORMDL3 in Pakistani asthmatics a case control study

RESEARCH Single nucleotide polymorphisms in asthma candidate genes TBXA2R, ADAM33 FCER1B and ORMDL3 in Pakistani asthmatics a case control study Nusrat Saba, Osman Yusuf, Sadia Rehman, Saeeda Munir, Amna Noor, Muhammad Saqlain, Atika Mansoor and Ghazala Kaukab Raja Asthma Research and Practice 2018, 4:4 | Published on: 22 March 2018 Abstract Background Genetic variations in different loci […]

Association of Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists With Asthma Control in Patients With Uncontrolled, Persistent Asthma A Systematic Review and Meta-analysis

JAMA Diana M. Sobieraj, PharmD1; William L. Baker, PharmD1; Elaine Nguyen, PharmD, MPH1; et alErin R. Weeda, PharmD1; Craig I. Coleman, PharmD1; C. Michael White, PharmD1; Stephen C. Lazarus, MD2; Kathryn V. Blake, PharmD3; Jason E. Lang, MD, MPH4   Author Affiliations Article Information JAMA. Published online March 19, 2018. doi:10.1001/jama.2018.2757   editorial comment icon  Editorial Comment related articles icon  Related Articles   Key Points Question  What is the efficacy associated with long-acting muscarinic antagonists (LAMAs) as add-on therapy to inhaled corticosteroids in patients […]

New Article From Asthma Research and Practice: Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice

Research – Open Access Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice Ning Zhang, Changwen Deng, Xingxing Zhang, Jingxi Zhang Email author and Chong Bai Asthma Research and Practice 2018 4:3 Abstract Background Asthma is a worldwide common chronic airway disease that cannot be cured and results in the huge burden in public health. Oxidative stress was considered an important […]

An algorithmic approach for the treatment of severe uncontrolled asthma

  Eleftherios Zervas, Konstantinos Samitas, Andriana I. Papaioannou, Petros Bakakos, Stelios Loukides, Mina Gaga ERJ Open Research 2018 4: 00125-2017; DOI: 10.1183/23120541.00125-2017 Abstract A small subgroup of patients with asthma suffers from severe disease that is either partially controlled or uncontrolled despite intensive, guideline-based treatment. These patients have significantly impaired quality of life and although they constitute <5% of all asthma patients, they are responsible for more than half of asthma-related […]

Effects of treatment changes on asthma phenotype prevalence and airway neutrophil function

BMC Pulmonary Medicine  BMC series – open, inclusive and trusted 2017 17:169 Collin R. Brooks, Christine J. Van Dalen, Elizabeth Harding, Ian F. Hermans and Jeroen Douwes Open Peer Review reports Abstract Background Asthma inflammatory phenotypes are often defined by relative cell counts of airway eosinophils/neutrophils. However, the importance of neutrophilia remains unclear, as does the effect of ICS treatment on asthma phenotypes and airway neutrophil function. The purpose […]

Automated chart review utilizing natural language processing algorithm for asthma predictive index

BMC Pulmonary Medicine 18:34, 2018 BMC series – open, inclusive and trusted  Research article – Open Access – Open Peer Review https://doi.org/10.1186/s12890-018-0593-9   Harsheen Kaur†, Sunghwan Sohn†, Chung-Il Wi, Euijung Ryu, Miguel A. Park, Kay Bachman, Hirohito Kita, Ivana Croghan, Jose A. Castro-Rodriguez, Gretchen A. Voge, Hongfang Liu, Young J. Juhn Open Peer Review reports Abstract Background Thus far, no algorithms have been developed to automatically extract patients who meet Asthma Predictive Index (API) criteria from the Electronic health records (EHR) yet. Our […]

Predictors of inappropriate and excessive use of reliever medications in asthma: a 16-year population-based study

Research article – Open Access – Open Peer Review BMC Pulmonary Medicine  BMC series – open, inclusive and trusted 2018 18:33 Hamid Tavakoli, J. Mark FitzGerald, Larry D. Lynd and Mohsen Sadatsafavi Open Peer Review reports Abstract Background Understanding factors associated with the inappropriate or excessive use of short-acting beta agonists (SABA) can help develop better policies. Methods We used British Columbian (BC)‘s administrative health […]

Test-retest repeatability of child’s respiratory symptoms and perceived indoor air quality – comparing self- and parent-administered questionnaires

BMC Pulmonary Medicine   Research article – Open Access – Open Peer Review   Jussi Lampi, Sari Ung-Lanki, Päivi Santalahti and Juha Pekkanen   BMC Pulmonary Medicine BMC series – open, inclusive and trusted 2018 18:32 Open Peer Review reports Abstract Background Questionnaires can be used to assess perceived indoor air quality and symptoms in schools. Questionnaires for primary school aged children have traditionally been […]

Nerve ablation after bronchial thermoplasty and sustained improvement in severe asthma

BMC Pulmonary Medicine   Research article – Open Access – Open Peer Review   N. Facciolongo, A. DiStefano, V. Pietrini, C. Galeone, F. Bellanova, F. Menzella, N. Scichilone, R. Piro, G. L. Bajocchi, B. Balbi, L. Agostini, P. P. Salsi, D. Formisano and M. Lusuardi   BMC Pulmonary Medicine BMC series – open, inclusive and trusted 201818:29 https://doi.org/10.1186/s12890-017-0554-8 Open Peer Review reports Abstract Background Bronchial thermoplasty (BT) is a non-pharmacological intervention for severe asthma whose mechanism of action is not completely explained by a reduction of airway […]