Year: 2018

Asthma Research and Practice: Effect of adjusting the combination of budesonide/formoterol on the alleviation of asthma symptoms

Research – Open Access Asthma Research and Practice 2018 4:7 Ryosuke Souma, Kumiya Sugiyama, Hiroyuki Masuda, Hajime Arifuku, Kentaro Nakano, Hiroyoshi Watanabe, Tomoshige Wakayama, Shingo Tokita, Masamitsu Tatewaki, Hideyuki Satoh, Kenya Koyama, Yumeko Hayashi, Fumiya Fukushima, Hirokuni Hirata, Masafumi Arima, Kazuhiro Kurasawa, Takeshi Fukuda and Yasutsugu Fukushima https://doi.org/10.1186/s40733-018-0043-8 Abstract Background The combination of budesonide + formoterol (BFC) offers the advantages of dose adjustment in a single inhaler according to asthma symptoms. We analyzed the relationship between asthma symptoms in terms of peak expiratory flow (PEF) and dose adjustment by the patient. Methods […]

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

Mario Castro, M.D., Jonathan Corren, M.D., Ian D. Pavord, M.D., Jorge Maspero, M.D., Sally Wenzel, M.D., Klaus F. Rabe, M.D., William W. Busse, M.D., Linda Ford, M.D., Lawrence Sher, M.D., J. Mark FitzGerald, M.D., Constance Katelaris, M.D., Yuji Tohda, M.D., et al. NEJM May 21, 2018DOI: 10.1056/NEJMoa1804092 AbstractBACKGROUNDDupilumab is a fully human anti–interleukin-4 receptor α monoclonal antibody that blocks both interleukin-4 and interleukin-13 signaling. We assessed its […]

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

N Eng J Med. May 21, 2018 DOI: 10.1056/NEJMoa1804093 Klaus F. Rabe, M.D., Ph.D., Parameswaran Nair, M.D., Ph.D., Guy Brusselle, M.D., Ph.D., Jorge F. Maspero, M.D., Mario Castro, M.D., Lawrence Sher, M.D., Hongjie Zhu, Ph.D., Jennifer D. Hamilton, Ph.D., Brian N. Swanson, Ph.D., Asif Khan, M.B., B.S., M.P.H., Jingdong Chao, Ph.D., Heribert Staudinger, M.D., Ph.D., […]

Clinical and Economic Impact of a One-Year Treatment With Omalizumab in Patients With Severe Allergic Asthma Within a Drug Programme in Poland

BMC Pulmonary Medicine Karina Jahnz-Różyk; Joanna Lis; Marta Warchoł; Aleksandra Kucharczyk BMC Pulm Med. 2018;18(48)  Abstract and Introduction Abstract Background Allergic asthma is the most prevalent phenotype of severe asthma where treatment with omalizumab (OMB) has been proven to be particularly beneficial. In Poland, OMB therapy is available and reimbursed within a drug programme where strict inclusion […]

Nerve ablation after bronchial thermoplasty and sustained improvement in severe asthma

Research article Open Access Open Peer Review BMC Pulmonary Medicine N. Facciolongo, A. DiStefano, V. Pietrini, C. Galeone, F. Bellanova, F. Menzella, N. Scichilone, R. Piro, G. L. Bajocchi, B. Balbi, L. Agostini, P. P. Salsi, D. Formisano and M. Lusuardi BMC Pulmonary Medicine BMC series – open, inclusive and trusted 2018 18:29 https://doi.org/10.1186/s12890-017-0554-8 Open Peer Review reports Abstract Background Bronchial thermoplasty (BT) is a non-pharmacological intervention for severe asthma whose mechanism of action is not completely explained by a reduction of airway smooth muscle (ASM). In […]

Prevalence of asthma among the adult general population of five Middle Eastern countries: results of the SNAPSHOT program

BMC Pulmonary Medicine   Research article – Open Access – Open Peer Review   Hesham Tarraf, Omur Aydin, Dilsad Mungan, Mohammad Albader, Bassam Mahboub, Adam Doble, Aaicha Lahlou, Luqman Tariq, Fayaz Aziz and Abdelkader El Hasnaoui BMC Pulmonary Medicine 2018 18:68 https://doi.org/10.1186/s12890-018-0621-9 Open Peer Review reports Abstract Background Asthma is a common chronic respiratory disease leading to morbidity, mortality and impaired quality of life worldwide. Information on asthma prevalence in the Middle East is fragmented and relatively […]

Loss of bronchoprotection to Salbutamol during sputum induction with hypertonic saline: implications for asthma therapy

Allergy, Asthma & Clinical Immunology Research Open Access   Hongyu Wang, Melanie Kjarsgaard, Terence Ho, John D. Brannan and Parameswaran Nair Allergy, Asthma & Clinical Immunology 2018 14:26 https://doi.org/10.1186/s13223-018-0256-7 Abstract Background Sputum induction with hypertonic saline in obstructive airway diseases is generally safe. However, saline induces bronchoconstriction in some patients despite pre-medication with Salbutamol. Our objectives were to investigate the predictors of failure of Salbutamol to protect […]

The following new article have just been published in Asthma Research and Practice: Associations of physical activity with childhood asthma, a population study based on the WHO – health behaviour in school-aged children survey

Asthma Research and Practice Lene Lochte, Poul Erik Petersen, Kim G. Nielsen, Anette Andersen and Thomas A. E. Platts-Mills Asthma Research and Practice 2018 4:6 https://doi.org/10.1186/s407 Abstract Background Asthma in paediatric populations is one of the highest public health concerns. In this study of children and adolescents, we hypothesized that low levels of physical activity (PA) would show associations with asthma that vary by asthma outcome. The objective was to […]